P048_0546_ Controlled drug delivery system of natural/synthetic silica structures to the dermis

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V. Rotaru

V.C. Macarel

C.D. Radu

E. Ulea

V. Hulea

A. Ungureanu

Florin Daniel Lipsa

Published Sep 5, 2019

Abstract

The paper is the first communication on an exploratory study of the use of three compounds: bentonite, clinoptilolite and SBA-15 (Santa Barbara Amorphous). The last component, SBA-15, is the cutting-edge result of a chemical synthesis with perspectives for use in the biochemical field, but also as a new controlled delivery system grafted on fibrous textile component for the release a drug from a textile to the dermis. Components are characterized in terms of the specific surface area (m2/g), pore size and sorption performance in relation to two antibacterial agents: silver sulfadiazine (4-amino-N- (pyrimidinyl) benzenesulfonamide, CAS no. 68-35-9) and silver nanoparticles obtained by reduction from an inorganic salt (AgNO3). Antibacterial agents are used in applications on burn wounds of large surface area and antibacterial bedding fabrics on a cellulosic structure. Subsequently the porous agent which presented maximum efficacy, as adsorption and drug delivery is grafted onto a 100% cotton knitted structure (interlock structure with yarns of Nm = 70/1 fineness). The experiments on kinetics of drug release from textile to solution are made at 37°C and pH = 5.5 according to standard of ISO 105-E04-2008E. The study determines the type of drug sorption isotherm, the zeolite absorption kinetics, the silver sulfadiazine molecular sizes and the in vitro drug delivery kinetics. As well, in the paper one presented the advantages and drawbacks of the delivery system.


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